Current Scholars in Marine Medicine

Current Scholars in Marine Medicine

Serene Cheng

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Bio: Before coming to Duke, I lived in Taiwan for 18 years. I’m currently a senior majoring in Biology and minoring in Visual and Media Studies. I grew an interest in marine science ever since I read the German novel “The Swarm” in middle school. After taking a field research course at Belize about marine ecology through Duke Marine Lab, I decided that it is something I want to pursue in the future. I interned at an NGO named The Royal Marine Conservation Society of Jordan this past summer, helping with the research and the graphic design work. Besides research, I have a passion in science communication. I own a YouTube channel with more than 100,000 subscribers. It is mainly about fashion and beauty, but I also strive to bring to light issues I’m passionate in, and inspire my audience to take action. I cooperated with the National Museum of Marine Biology & Aquarium in Taiwan to host events and talks on environmental topics. I am beyond grateful to join this program and I look forward to my remaining year with this amazing community!

Research: For organisms with large body mass, a major constraint on the evolution is the increased risk of developing cancer. If all cells have a similar risk of malignant mutation and equivalent cancer suppression mechanisms, organisms with more cells would be expected to have higher rates of cancer-causing mutations than organisms with fewer cells. Yet, this isn’t true. This lack of correlation between body size and cancer risk is known as Peto’s Paradox. Among the mechanisms that large animals may have evolved that resolve Peto’s paradox are an increase in the copy number of TP53, a tumor suppressor gene. Sperm whales, however, only have one copy of TP53 gene; therefore, we hypothesize that the tumor suppression activities of TP53 in sperm whale are stronger than human TP53. Our goal is to investigate the TP53 gene of sperm whale and its tumor suppression activity as a potential mechanism to explain how they have evolved enhanced resistance to cancer.

Parker Matthews

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Bio: My name is Parker Mathews, and I am a rising senior Biology major at Duke University. I was born and raised in Kansas City, where I became interested in medicine while volunteering in an emergency room. I had the amazing opportunity to study at the Duke Marine Lab in Beaufort, NC during the Spring 2018 semester, and travel with faculty to Belize and Singapore. During my semester at the marine lab, I grew passionate about the oceans and marine life, and am currently spending this summer here conducting a research independent study as a Scholar in Marine Medicine. Outside of the lab, I work for a rescue squad as an Emergency Medical Technician in Franklin County, NC. I have also worked as an analyst for two companies providing emergency telemedicine and teleneurology services to individuals, travelers, hospitals, and the government. In my free time, I love golf, travelling, mountain biking, and Kansas City sports.

Research: My Scholars in Marine Medicine project is co-sponsored by Dr. Tom Schultz at the Duke Marine Lab and Dr. Jason Somarelli at the Duke Cancer Institute. My project ties into a much larger, decades-long attempt to understand the adapted resistance of certain populations of the Atlantic killifish (Fundulus heteroclitus) to environmental carcinogens and teratogens (PAHs, PCBs, dioxins, etc.). Advances in DNA sequencing technology have given researchers new tools to analyze genetic variation within- and between- populations of these fish. My work at the Duke Marine Lab is primarily grounded in bioinformatics, attempting to leverage existing data on regions/targets of selection between adapted and non-adapted populations of killifish to learn more about the roles of specific genes in the adapted toxicity-resistant phenotype. Specifically, my project is looking at a group of genes involved in the aryl hydrocarbon receptor pathway, including the aryl hydrocarbon nuclear translocator (ARNT). In addition to its role in the metabolism of environmental toxins, ARNT is also the beta subunit of the hypoxia-inducible factor 1 (HIF1), which is known to play a role in tumor progression in many cancers. The overall goal of this project is to continue this research at the Duke Cancer Institute and apply findings from adapted carcinogen/teratogen resistance in killifish to mouse or human cell lines to better understand ways to combat exposures to environmental carcinogens.

Maya Sheth

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Bio: I am a rising junior at Duke studying Biomedical Engineering. I first fell in love with the oceans in the second grade when I watched Free Willy, did a research project on orcas and started swimming competitively. Growing up, I spent more time in or thinking about the water than just about anything else. At Duke, I am involved with the organization Duke Conservation Tech (DCT), where I learned of the unexplored potential of applying techniques from medical and tech fields to the conservation movement and vice versa. Through DCT, I was a co-organizer of a sustainable tech ideation conference, Blueprint, where I was first introduced to Duke’s Comparative Oncology Lab. I look forward to continuing my design and research work with them in the coming years!