Celia J. Bonaventura

Celia J. Bonaventura

Professor Emeritus

Major Research Area: NIH grants support studies of structure/function relationships of oxygen and electron-transport proteins. Human proteins are compared to those of marine organisms in structure/function assays. Assays involve equilibrium measurements and complementary studies of rapid reaction kinetics, using UV/VIS and fluorescence spectroscopy and novel methods of spectroelectrochemistry. This work has led to an increased understanding of molecular adaptations in the respiratory proteins, with a focus on interactions with nitric oxide and reactive oxygen species. My comparative studies illustrate aspects of environmental adaptations and mechanisms of toxicity associated with exposure to free radicals and metals. Environmental Education Grants: NSF and Burroughs Welcome grants foster new approaches to communication of environmental problems, coupling the research interests of Duke students and K-12 teachers and students. Director, Duke University Marine/freshwater Biomedical Center

SELECTED PUBLICATIONS

Bonaventura, Celia, Robert Henkens, Abdu I. Alayash, Sambuddha Banerjee, and Alvin L. Crumbliss. “Molecular controls of the oxygenation and redox reactions of hemoglobin..” Antioxidants & Redox Signaling 18, no. 17 (June 2013): 2298–2313. https://doi.org/10.1089/ars.2012.4947.
Banerjee, Sambuddha, Yiping Jia, Claire J Parker Siburt, Bindu Abraham, Francine Wood, Celia Bonaventura, Robert Henkens, Alvin L. Crumbliss, and Abdu I. Alayash. “Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions..” Free Radical Biology & Medicine 53, no. 6 (September 2012): 1317–26. https://doi.org/10.1016/j.freeradbiomed.2012.07.023.
Bonaventura, Celia, Robert Henkens, Joel Friedman, Claire J Parker Siburt, Daniel Kraiter, and Alvin L. Crumbliss. “Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins..” Biochimica Et Biophysica Acta 1814, no. 10 (October 2011): 1261–68. https://doi.org/10.1016/j.bbapap.2011.06.012.
Bonaventura, Celia, Robert Henkens, Walleska De Jesus-Bonilla, Juan Lopez-Garriga, Yiping Jia, Abdu I. Alayash, Claire J Parker Siburt, and Alvin L. Crumbliss. “Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite..” Biochimica Et Biophysica Acta 1804, no. 10 (October 2010): 1988–95. https://doi.org/10.1016/j.bbapap.2010.06.016.
Bonaventura, C. J., R. Henkens, C. Siburt, A. I. Alayash, and A. Crumbliss. “Extreme Differences in Lucina Hemoglobins in their Interactions wtih Nitrite.” Biochemica Biophysica Acta, March 2010.

Recent Grants

area(s) of expertise

Environmental Chemistry

Contact Information

135 Duke Marine Lab Rd
Beaufort, NC 28516

Education

Ph.D., University of Texas at Austin (1968)
B.A., San Diego State University (1964)