Celia J. Bonaventura
Celia J. Bonaventura
Major Research Area: NIH grants support studies of structure/function relationships of oxygen and electron-transport proteins. Human proteins are compared to those of marine organisms in structure/function assays. Assays involve equilibrium measurements and complementary studies of rapid reaction kinetics, using UV/VIS and fluorescence spectroscopy and novel methods of spectroelectrochemistry. This work has led to an increased understanding of molecular adaptations in the respiratory proteins, with a focus on interactions with nitric oxide and reactive oxygen species. My comparative studies illustrate aspects of environmental adaptations and mechanisms of toxicity associated with exposure to free radicals and metals. Environmental Education Grants: NSF and Burroughs Welcome grants foster new approaches to communication of environmental problems, coupling the research interests of Duke students and K-12 teachers and students. Director, Duke University Marine/freshwater Biomedical Center
Bonaventura, C, Henkens, R, Alayash, AI, Banerjee, S, and Crumbliss, AL. "Molecular controls of the oxygenation and redox reactions of hemoglobin." Antioxidants & redox signaling 18, no. 17 (June 2013): 2298-2313. (Review)
Banerjee, S, Jia, Y, Siburt, CJP, Abraham, B, Wood, F, Bonaventura, C, Henkens, R, Crumbliss, AL, and Alayash, AI. "Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions." Free Radic Biol Med 53, no. 6 (September 15, 2012): 1317-1326.
Bonaventura, C, Henkens, R, Friedman, J, Siburt, CJP, Kraiter, D, and Crumbliss, AL. "Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins." Biochim Biophys Acta 1814, no. 10 (October 2011): 1261-1268.
Bonaventura, C, Henkens, R, De Jesus-Bonilla, W, Lopez-Garriga, J, Jia, Y, Alayash, AI, Siburt, CJP, and Crumbliss, AL. "Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite." Biochim Biophys Acta 1804, no. 10 (October 2010): 1988-1995.
Bonaventura, CJ, Henkens, R, Siburt, C, Alayash, AI, and Crumbliss, A. "Extreme Differences in Lucina Hemoglobins in their Interactions wtih Nitrite." Biochemica Biophysica Acta (March 2010). (Academic Article)
(95-0524) Marine/Freshwater Biomedical Center Grant awarded by National Institute of Environmental Health Science
area(s) of expertiseEnvironmental Chemistry
135 Duke Marine Lab Rd
Beaufort, NC 28516
Ph.D., University of Texas at Austin (1968)
B.A., San Diego State University (1964)