Richard T. Di Giulio

Richard T. Di Giulio

Sally Kleberg Professor of Environmental Toxicology

Interim ESP Division Chair

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

In The News

SELECTED PUBLICATIONS

Pitt, JA, Trevisan, R, Massarsky, A, Kozal, JS, Levin, ED, and Di Giulio, RT. "Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene.(Accepted)" The Science of the Total Environment 643 (December 2018): 324-334.

Massarsky, A, Jayasundara, N, Glazer, L, Levin, ED, Prasad, GL, and Di Giulio, RT. "Outcomes of developmental exposure to total particulate matter from cigarette smoke in zebrafish (Danio rerio)." Neurotoxicology 68 (July 17, 2018): 101-114.

Osterberg, JS, Cammen, KM, Schultz, TF, Clark, BW, and Di Giulio, RT. "Genome-wide scan reveals signatures of selection related to pollution adaptation in non-model estuarine Atlantic killifish (Fundulus heteroclitus)." Aquatic Toxicology (Amsterdam, Netherlands) 200 (July 2018): 73-82.

Massarsky, A, Abdel, A, Glazer, L, Levin, ED, and Di Giulio, RT. "Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio)." Neurotoxicology 65 (March 2018): 111-124.

Massarsky, A, Prasad, GL, and Di Giulio, RT. "Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio)." Toxicology and Applied Pharmacology 339 (January 2018): 85-96.

Recent Grants

Courses

ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
ENVIRON 537: Environmental Health (ENVIRON 537: Environmental Health)
ENVIRON 899: Master's Project (ENVIRON 899: Master's Project)

Contact Information

A346B Lev Sci Res Ctr
Durham, NC 27708
Box 90328
Durham, NC 27708-0328

Education

Ph.D., Virginia Polytech Institute and State University (1982)
M.S., Louisiana State University at Baton Rouge (1978)
B.A., University of Texas at Austin (1972)