Richard T. Di Giulio

Richard T. Di Giulio

Sally Kleberg Professor of Environmental Toxicology

Interim ESP Division Chair

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

In The News


Massarsky, A, Abdel, A, Glazer, L, Levin, ED, and Di Giulio, RT. "Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio)." Neurotoxicology 65 (March 2018): 111-124.
Massarsky, A, Prasad, GL, and Di Giulio, RT. "Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio)." Toxicology and applied pharmacology 339 (January 2018): 85-96.
Pitt, JA, Kozal, JS, Jayasundara, N, Massarsky, A, Trevisan, R, Geitner, N, Wiesner, M, Levin, ED, and Di Giulio, RT. "Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)." Aquatic toxicology (Amsterdam, Netherlands) 194 (January 2018): 185-194.
Brown, DR, Thompson, J, Chernick, M, Hinton, DE, and Di Giulio, RT. "Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus)." Environmental toxicology and chemistry 36, no. 12 (December 2017): 3246-3253.
Hartman, JH, Kozal, JS, Di Giulio, RT, and Meyer, JN. "Zebrafish have an ethanol-inducible hepatic 4-nitrophenol hydroxylase that is not CYP2E1-like." Environmental toxicology and pharmacology 54 (September 2017): 142-145.

Recent Grants


ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 501A: Environmental Toxicology (ENVIRON 501A: Environmental Toxicology)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
ENVIRON 537: Environmental Health (ENVIRON 537: Environmental Health)

Contact Information

A346B Lev Sci Res Ctr
Durham, NC 27708
Box 90328
Durham, NC 27708-0328


Ph.D., Virginia Polytech Institute and State University (1982)
M.S., Louisiana State University at Baton Rouge (1978)
B.A., University of Texas at Austin (1972)