Richard T. Di Giulio

Richard T. Di Giulio

Sally Kleberg Professor of Environmental Toxicology

Interim ESP Division Chair

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

In The News


Pitt, JA, Kozal, JS, Jayasundara, N, Massarsky, A, Trevisan, R, Geitner, N, Wiesner, M, Levin, ED, and Di Giulio, RT. "Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio). (Accepted)" Aquatic toxicology (Amsterdam, Netherlands) 194 (January 2018): 185-194.
Brown, DR, Thompson, J, Chernick, M, Hinton, DE, and Di Giulio, RT. "Later life swimming performance and persistent heart damage following subteratogenic PAH mixture exposure in the Atlantic killifish (Fundulus heteroclitus)." Environmental toxicology and chemistry 36, no. 12 (December 2017): 3246-3253.
Mu, J, Chernick, M, Dong, W, Di Giulio, RT, and Hinton, DE. "Early life co-exposures to a real-world PAH mixture and hypoxia result in later life and next generation consequences in medaka (Oryzias latipes)." Aquatic toxicology (Amsterdam, Netherlands) 190 (September 2017): 162-173.
Yang, Y, Chen, B, Hower, J, Schindler, M, Winkler, C, Brandt, J, Di Giulio, R, Ge, J, Liu, M, Fu, Y, Zhang, L, Chen, Y, Priya, S, and Hochella, MF. "Discovery and ramifications of incidental Magnéli phase generation and release from industrial coal-burning." Nature communications 8, no. 1 (August 8, 2017): 194-.
Jayasundara, N, Fernando, PW, Osterberg, JS, Cammen, KM, Schultz, TF, and Di Giulio, RT. "Cost of Tolerance: Physiological Consequences of Evolved Resistance to Inhabit a Polluted Environment in Teleost Fish Fundulus heteroclitus." Environmental science & technology 51, no. 15 (August 2017): 8763-8772.

Recent Grants


ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
ENVIRON 537: Environmental Health (ENVIRON 537: Environmental Health)
ENVIRON 899: Master's Project (ENVIRON 899: Master's Project)

Contact Information

A346B Lev Sci Res Ctr
Durham, NC 27708
Box 90328
Durham, NC 27708-0328


Ph.D., Virginia Polytech Institute and State University (1982)
M.S., Louisiana State University at Baton Rouge (1978)
B.A., University of Texas at Austin (1972)