Richard T. Di Giulio

Richard T. Di Giulio

Professor of Environmental Toxicology

Interim ESP Division Chair

Dr. Di Giulio serves as Director of Duke University's Integrated Toxicology Program and the Superfund Basic Research Center. Dr. Di Giulio's research is concerned with basic studies of mechanisms of contaminant metabolism, adaptation and toxicity, and with the development of mechanistically-based indices of exposure and toxicity that can be employed in biomonitoring. The long term goals of this research are to bridge the gap between mechanistic toxicological research and the development of useful tools for environmental assessment, and to elucidate linkages between human and ecosystem health. The bulk of Dr. Di Giulio's work employs a comparative approach with aquatic animals, particularly fishes, as models. Of particular concern are mechanisms of oxidative metabolism of aromatic hydrocarbons, mechanisms of free radical production and antioxidant defense, and mechanisms of chemical carcinogenesis, developmental perturbations and adaptations to contaminated environments by fishes.

In The News

SELECTED PUBLICATIONS

Brown, DR, Clark, BW, Garner, LVT, and Di Giulio, RT. "Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus)." Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 188 (October 2016): 45-51.
Matson, CW, Bone, AJ, Auffan, M, Lindberg, TT, Arnold, MC, Hsu-Kim, H, Wiesner, MR, and Di Giulio, RT. "Silver toxicity across salinity gradients: the role of dissolved silver chloride species (AgCl x ) in Atlantic killifish (Fundulus heteroclitus) and medaka (Oryzias latipes) early life-stage toxicity." Ecotoxicology (London, England) 25, no. 6 (August 2016): 1105-1118.
Riley, AK, Chernick, M, Brown, DR, Hinton, DE, and Di Giulio, RT. "Hepatic Responses of Juvenile Fundulus heteroclitus from Pollution-adapted and Nonadapted Populations Exposed to Elizabeth River Sediment Extract." Toxicologic pathology 44, no. 5 (July 2016): 738-748.
Arnold, MC, Forte, JE, Osterberg, JS, and Di Giulio, RT. "Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos." Archives of environmental contamination and toxicology 70, no. 2 (February 2016): 311-320.
Brown, DR, Bailey, JM, Oliveri, AN, Levin, ED, and Di Giulio, RT. "Developmental exposure to a complex PAH mixture causes persistent behavioral effects in naive Fundulus heteroclitus (killifish) but not in a population of PAH-adapted killifish." Neurotoxicology and teratology 53 (January 2016): 55-63.

Courses

ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
ENVIRON 537: Environmental Health (ENVIRON 537: Environmental Health)
ENVIRON 899: Master's Project (ENVIRON 899: Master's Project)

Contact Information

A346B Lev Sci Res Ctr
Durham, NC 27708
Box 90328
Durham, NC 27708-0328

Education

Ph.D., Virginia Polytech Institute and State University (1982)
M.S., Louisiana State University at Baton Rouge (1978)
B.A., University of Texas at Austin (1972)