Natalie Johnson, PhD, Texas A&M University will present.
Particulate matter (PM), a major component of ambient air pollution, accounts for a substantial burden of diseases and death worldwide. Maternal exposure to PM during pregnancy is particularly harmful to children’s health since this is a phase of rapid human growth and development. In this seminar, Dr. Johnson will highlight recent findings from her mouse model of prenatal ultrafine particle (UFP) exposure. Her findings demonstrate in utero UFP exposure leads to dysregulated bile acid/lipid homeostasis through increased FXR expression in placenta and fetal lung tissue, augmented in female offspring.