P. Lee Ferguson

P. Lee Ferguson

Associate Professor of Environmental Chemistry and Engineering

Dr. Ferguson is an Environmental Analytical Chemist who joined Duke in 2009 after six years as an assistant professor in the Department of Chemistry & Biochemistry at the University of South Carolina.

Research in the Ferguson laboratory is focused on development of novel methods for trace analysis of organic and nanoparticulate contaminants in the aquatic environment. Specifically, the laboratory uses high performance mass spectrometry techniques (e.g. UHPLC-Orbitrap MS/MS) to detect, identify, and quantify emerging contaminants (including endocrine disruptors, pharmaceuticals, and surfactants) in wastewater and drinking water. Another significant research thrust involves the development of sensitive trace analytical techniques for quantifying and characterizing single-walled carbon nanotubes in water, sediment, and aquatic organism tissues. For this work, near infrared fluorescence spectroscopy (NIRF) is used as a primary tool for resolving these novel nanoparticulate contaminants in highly complex environmental mixtures.

The analytical methods developed in the Ferguson laboratory laboratory (for both nanoparticles and organic contaminants) are applied to both process-oriented environmental chemistry experiments in the field and laboratory as well as to toxicity bioassays (including whole-organism assays and molecular endpoints). The overarching goal is to gain an increased understanding of how emerging contaminants are transported, transformed and induce deleterious effects within aquatic ecosystems.

In The News


Cooper, EM, Kroeger, G, Davis, K, Clark, CR, Ferguson, PL, and Stapleton, HM. "Results from Screening Polyurethane Foam Based Consumer Products for Flame Retardant Chemicals: Assessing Impacts on the Change in the Furniture Flammability Standards." Environmental science & technology 50, no. 19 (October 2016): 10653-10660.
Smith, LC, Clark, JC, Bisesi, JH, Ferguson, PL, and Sabo-Attwood, T. "Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens." Comparative biochemistry and physiology. Part D, Genomics & proteomics 19 (September 2016): 159-173.
Hoelzer, K, Sumner, AJ, Karatum, O, Nelson, RK, Drollette, BD, O'Connor, MP, D'Ambro, EL, Getzinger, GJ, Ferguson, PL, Reddy, CM, Elsner, M, and Plata, DL. "Indications of Transformation Products from Hydraulic Fracturing Additives in Shale-Gas Wastewater." Environmental science & technology 50, no. 15 (August 2016): 8036-8048.
Smith, LC, Ralston-Hooper, KJ, Ferguson, PL, and Sabo-Attwood, T. "The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures." Toxicological sciences : an official journal of the Society of Toxicology 151, no. 2 (June 2016): 434-446.
Holden, PA, Gardea-Torresdey, JL, Klaessig, F, Turco, RF, Mortimer, M, Hund-Rinke, K, Cohen Hubal, EA, Avery, D, Barceló, D, Behra, R, Cohen, Y, Deydier-Stephan, L, Ferguson, PL, Fernandes, TF, Herr Harthorn, B, Henderson, WM, Hoke, RA, Hristozov, D, Johnston, JM, Kane, AB, Kapustka, L, Keller, AA, Lenihan, HS, Lovell, W, Murphy, CJ, Nisbet, RM, Petersen, EJ, Salinas, ER, Scheringer, M, Sharma, M, Speed, DE, Sultan, Y, Westerhoff, P, White, JC, Wiesner, MR, Wong, EM, Xing, B, and Steele Horan, M et al. "Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials." Environmental science & technology 50, no. 12 (June 2016): 6124-6145.


ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
CEE 461L: Chemical Principles in Environmental Engineering (CEE 461L: Chemical Principles in Environmental Engineering)
ENVIRON 566: Environmental Analytical Chemistry (ENVIRON 566: Environmental Analytical Chemistry)
ENVIRON 542L: Environmental Aquatic Chemistry (ENVIRON 542L: Environmental Aquatic Chemistry)
CEE 561L: Environmental Aquatic Chemistry (CEE 561L: Environmental Aquatic Chemistry)

Contact Information

Box 90287, 121 Hudson Hall
Durham, NC 27708-0287
Gross Hall, Room 379, Dept. of Civil & Environ. Engineering
Durham, NC 27708


Ph.D., State University of New York at Stony Brook (2002)