Truman and Nellie Semans/Alex Brown & Sons Associate Professor of Molecular Environmental Toxicology
DGS of UPEH program
Dr. Meyer studies the effects of toxic agents and stressors on human and wildlife health. He is particularly interested in understanding the mechanisms by which environmental agents cause DNA damage, the molecular processes that organisms employ to protect prevent and repair DNA damage, and genetic differences that may lead to increased or decreased sensitivity to DNA damage. Mitochondrial DNA damage and repair, as well as mitochondrial function in general, are a particular focus. He studies these effects in the nematode Caenorhabditis elegans, in cell culture, and collaboratively in other laboratory model organisms as well as in human populations in the USA and globally.
In The News
Luz, AL, Godebo, TR, Bhatt, DP, Ilkayeva, OR, Maurer, LL, Hirschey, MD, and Meyer, JN. "From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans." Toxicological Sciences : an Official Journal of the Society of Toxicology 152, no. 2 (August 2016): 349-362.
González-Hunt, CP, Leung, MCK, Bodhicharla, RK, McKeever, MG, Arrant, AE, Margillo, KM, Ryde, IT, Cyr, DD, Kosmaczewski, SG, Hammarlund, M, and Meyer, JN. "Exposure to mitochondrial genotoxins and dopaminergic neurodegeneration in Caenorhabditis elegans." Plos One 9, no. 12 (January 2014): e114459-null.
Meyer, JN, Leung, MCK, Rooney, JP, Sendoel, A, Hengartner, MO, Kisby, GE, and Bess, AS. "Mitochondria as a target of environmental toxicants." Toxicological Sciences : an Official Journal of the Society of Toxicology 134, no. 1 (July 2013): 1-17. (Review)
Bess, AS, Crocker, TL, Ryde, IT, and Meyer, JN. "Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans." Nucleic Acids Research 40, no. 16 (September 2012): 7916-7931.