Susan Kay Murphy

Susan Kay Murphy

Associate Professor

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease

SELECTED PUBLICATIONS

Murphy, SK, Adigun, A, Huang, Z, Overcash, F, Wang, F, Jirtle, RL, Schildkraut, JM, Murtha, AP, Iversen, ES, and Hoyo, C. "Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke." Gene 494, no. 1 (February 15, 2012): 36-43.
Matsumura, N, Huang, Z, Mori, S, Baba, T, Fujii, S, Konishi, I, Iversen, ES, Berchuck, A, and Murphy, SK. "Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer." Genome Res 21, no. 1 (January 2011): 74-82.
Kondoh, E, Mori, S, Yamaguchi, K, Baba, T, Matsumura, N, Cory Barnett, J, Whitaker, RS, Konishi, I, Fujii, S, Berchuck, A, and Murphy, SK. "Targeting slow-proliferating ovarian cancer cells." Int J Cancer 126, no. 10 (May 15, 2010): 2448-2456.
Yamaguchi, K, Mandai, M, Oura, T, Matsumura, N, Hamanishi, J, Baba, T, Matsui, S, Murphy, SK, and Konishi, I. "Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes." Oncogene 29, no. 12 (March 25, 2010): 1741-1752.
Lee, PS, Teaberry, VS, Bland, AE, Huang, Z, Whitaker, RS, Baba, T, Fujii, S, Secord, AA, Berchuck, A, and Murphy, SK. "Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer." Int J Cancer 126, no. 6 (March 15, 2010): 1378-1389.
Murphy, SK. "Targeting ovarian cancer-initiating cells." Anticancer Agents Med Chem 10, no. 2 (February 2010): 157-163. (Review)
Hoyo, C, Murphy, SK, and Jirtle, RL. "Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies." J Epidemiol Community Health 63, no. 9 (September 2009): 683-684.
Matsumura, N, Huang, Z, Baba, T, Lee, PS, Barnett, JC, Mori, S, Chang, JT, Kuo, W-L, Gusberg, AH, Whitaker, RS, Gray, JW, Fujii, S, Berchuck, A, and Murphy, SK. "Yin yang 1 modulates taxane response in epithelial ovarian cancer." Mol Cancer Res 7, no. 2 (February 2009): 210-220.
Baba, T, Convery, PA, Matsumura, N, Whitaker, RS, Kondoh, E, Perry, T, Huang, Z, Bentley, RC, Mori, S, Fujii, S, Marks, JR, Berchuck, A, and Murphy, SK. "Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells." Oncogene 28, no. 2 (January 15, 2009): 209-218.
Weidman, JR, Dolinoy, DC, Murphy, SK, and Jirtle, RL. "Cancer susceptibility: epigenetic manifestation of environmental exposures." Cancer J 13, no. 1 (January 2007): 9-16. (Review)
Murphy, SK, Huang, Z, Wen, Y, Spillman, MA, Whitaker, RS, Simel, LR, Nichols, TD, Marks, JR, and Berchuck, A. "Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer." Mol Cancer Res 4, no. 4 (April 2006): 283-292.
Murphy, SK, Nolan, CM, Huang, Z, Kucera, KS, Freking, BA, Smith, TPL, Leymaster, KA, Weidman, JR, and Jirtle, RL. "Callipyge mutation affects gene expression in cis: a potential role for chromatin structure." Genome Res 16, no. 3 (March 2006): 340-346.
Huang, Z, Wen, Y, Shandilya, R, Marks, JR, Berchuck, A, and Murphy, SK. "High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. (Published online)" Nucleic Acids Res 34, no. 2 (2006): 555-563.
Berchuck, A, Iversen, ES, Lancaster, JM, Pittman, J, Luo, J, Lee, P, Murphy, S, Dressman, HK, Febbo, PG, West, M, Nevins, JR, and Marks, JR. "Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers." Clin Cancer Res 11, no. 10 (May 15, 2005): 3686-3696.
Murphy, SK, Freking, BA, Smith, TPL, Leymaster, K, Nolan, CM, Wylie, AA, Evans, HK, and Jirtle, RL. "Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep." Mamm Genome 16, no. 3 (March 2005): 171-183.
Murphy, SK, Wylie, AA, Coveler, KJ, Cotter, PD, Papenhausen, PR, Sutton, VR, Shaffer, LG, and Jirtle, RL. "Epigenetic detection of human chromosome 14 uniparental disomy." Hum Mutat 22, no. 1 (July 2003): 92-97.
Murphy, SK, and Jirtle, RL. "Imprinting evolution and the price of silence." Bioessays 25, no. 6 (June 2003): 577-588. (Review)
Freking, BA, Murphy, SK, Wylie, AA, Rhodes, SJ, Keele, JW, Leymaster, KA, Jirtle, RL, and Smith, TPL. "Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals." Genome Res 12, no. 10 (October 2002): 1496-1506.
Murphy, SK, Wylie, AA, and Jirtle, RL. "Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior." Genomics 71, no. 1 (January 1, 2001): 110-117.
Wylie, AA, Murphy, SK, Orton, TC, and Jirtle, RL. "Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation." Genome Res 10, no. 11 (November 2000): 1711-1718.
Murphy, SK, and Jirtle, RL. "Imprinted genes as potential genetic and epigenetic toxicologic targets." Environ Health Perspect 108 Suppl 1 (March 2000): 5-11. (Review)
Cordero, FJ, Huang, Z, Grenier, C, He, X, Hu, G, McLendon, RE, Murphy, SK, Hashizume, R, and Becher, OJ. "Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG." Molecular cancer research : MCR (May 18, 2017).
Luo, Y, McCullough, LE, Tzeng, J-Y, Darrah, T, Vengosh, A, Maguire, RL, Maity, A, Samuel-Hodge, C, Murphy, SK, Mendez, MA, and Hoyo, C. "Maternal blood cadmium, lead and arsenic levels, nutrient combinations, and offspring birthweight." BMC Public Health 17, no. 1 (April 24, 2017): 354-.
Breton, CV, Marsit, CJ, Faustman, E, Nadeau, K, Goodrich, JM, Dolinoy, DC, Herbstman, J, Holland, N, LaSalle, JM, Schmidt, R, Yousefi, P, Perera, F, Joubert, BR, Wiemels, J, Taylor, M, Yang, IV, Chen, R, Hew, KM, Freeland, DMH, Miller, R, and Murphy, SK. "Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group." Environmental health perspectives 125, no. 4 (April 2017): 511-526.
Mwinyi, J, Boström, AE, Pisanu, C, Murphy, SK, Erhart, W, Schafmayer, C, Hampe, J, Moylan, C, and Schiöth, HB. "NAFLD is associated with methylation shifts with relevance for the expression of genes involved in lipoprotein particle composition." Biochimica et biophysica acta 1862, no. 3 (March 2017): 314-323.
Hoffman, K, Butt, CM, Webster, TF, Preston, EV, Hammel, SC, Makey, C, Lorenzo, AM, Cooper, EM, Carignan, C, Meeker, JD, Hauser, R, Soubry, A, Murphy, SK, Price, TM, Hoyo, C, Mendelsohn, E, Congleton, J, Daniels, JL, and Stapleton, HM. "Temporal Trends in Exposure to Organophosphate Flame Retardants in the United States." Environmental science & technology letters 4, no. 3 (March 2017): 112-118.

Courses

PATHOL 293: Research Independent Study (PATHOL 293: Research Independent Study)

Contact Information

Box 91012
Durham, NC 27708-1012
226 B Wing LSRC, 450 Research Drive
Durham, NC 27708

Education

Ph.D., Wake Forest University (1998)
B.A., University of North Carolina at Charlotte (1992)