Susan Kay Murphy

Susan Kay Murphy

Associate Professor

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

SELECTED PUBLICATIONS

Murphy, SK, Adigun, A, Huang, Z, Overcash, F, Wang, F, Jirtle, RL, Schildkraut, JM, Murtha, AP, Iversen, ES, and Hoyo, C. "Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke." Gene 494, no. 1 (February 2012): 36-43.
Murphy, SK, Huang, Z, and Hoyo, C. "Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues." Plos One 7, no. 7 (January 2012): e40924-null.
Matsumura, N, Huang, Z, Mori, S, Baba, T, Fujii, S, Konishi, I, Iversen, ES, Berchuck, A, and Murphy, SK. "Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer." Genome Res 21, no. 1 (January 2011): 74-82.
Kondoh, E, Mori, S, Yamaguchi, K, Baba, T, Matsumura, N, Cory Barnett, J, Whitaker, RS, Konishi, I, Fujii, S, Berchuck, A, and Murphy, SK. "Targeting slow-proliferating ovarian cancer cells." Int J Cancer 126, no. 10 (May 15, 2010): 2448-2456.
Lee, PS, Teaberry, VS, Bland, AE, Huang, Z, Whitaker, RS, Baba, T, Fujii, S, Secord, AA, Berchuck, A, and Murphy, SK. "Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer." Int J Cancer 126, no. 6 (March 15, 2010): 1378-1389.
Yamaguchi, K, Mandai, M, Oura, T, Matsumura, N, Hamanishi, J, Baba, T, Matsui, S, Murphy, SK, and Konishi, I. "Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes." Oncogene 29, no. 12 (March 2010): 1741-1752.
Murphy, SK. "Targeting ovarian cancer-initiating cells." Anticancer Agents Med Chem 10, no. 2 (February 2010): 157-163. (Review)
Hoyo, C, Murphy, SK, and Jirtle, RL. "Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies." Journal of Epidemiology and Community Health 63, no. 9 (September 2009): 683-684.
Matsumura, N, Huang, Z, Baba, T, Lee, PS, Barnett, JC, Mori, S, Chang, JT, Kuo, W-L, Gusberg, AH, Whitaker, RS, Gray, JW, Fujii, S, Berchuck, A, and Murphy, SK. "Yin yang 1 modulates taxane response in epithelial ovarian cancer." Molecular Cancer Research : Mcr 7, no. 2 (February 10, 2009): 210-220.
Baba, T, Convery, PA, Matsumura, N, Whitaker, RS, Kondoh, E, Perry, T, Huang, Z, Bentley, RC, Mori, S, Fujii, S, Marks, JR, Berchuck, A, and Murphy, SK. "Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells." Oncogene 28, no. 2 (January 15, 2009): 209-218.
Price, TM, Murphy, SK, and Younglai, EV. "Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors." Toxicological Sciences : an Official Journal of the Society of Toxicology 96, no. 2 (April 2007): 218-226. (Review)
Weidman, JR, Dolinoy, DC, Murphy, SK, and Jirtle, RL. "Cancer susceptibility: epigenetic manifestation of environmental exposures." Cancer Journal (Sudbury, Mass.) 13, no. 1 (January 2007): 9-16. (Review)
Murphy, SK, Huang, Z, Wen, Y, Spillman, MA, Whitaker, RS, Simel, LR, Nichols, TD, Marks, JR, and Berchuck, A. "Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer." Mol Cancer Res 4, no. 4 (April 2006): 283-292.
Murphy, SK, Nolan, CM, Huang, Z, Kucera, KS, Freking, BA, Smith, TPL, Leymaster, KA, Weidman, JR, and Jirtle, RL. "Callipyge mutation affects gene expression in cis: a potential role for chromatin structure." Genome Research 16, no. 3 (March 2006): 340-346. (Letter)
Huang, Z, Wen, Y, Shandilya, R, Marks, JR, Berchuck, A, and Murphy, SK. "High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer. (Published online)" Nucleic Acids Res 34, no. 2 (2006): 555-563.
Berchuck, A, Iversen, ES, Lancaster, JM, Pittman, J, Luo, J, Lee, P, Murphy, S, Dressman, HK, Febbo, PG, West, M, Nevins, JR, and Marks, JR. "Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers." Clin Cancer Res 11, no. 10 (May 15, 2005): 3686-3696.
Murphy, SK, Freking, BA, Smith, TPL, Leymaster, K, Nolan, CM, Wylie, AA, Evans, HK, and Jirtle, RL. "Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep." Mammalian Genome : Official Journal of the International Mammalian Genome Society 16, no. 3 (March 2005): 171-183.
Murphy, SK, Wylie, AA, Coveler, KJ, Cotter, PD, Papenhausen, PR, Sutton, VR, Shaffer, LG, and Jirtle, RL. "Epigenetic detection of human chromosome 14 uniparental disomy." Human Mutation 22, no. 1 (July 2003): 92-97.
Murphy, SK, and Jirtle, RL. "Imprinting evolution and the price of silence." Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology 25, no. 6 (June 2003): 577-588. (Review)
Freking, BA, Murphy, SK, Wylie, AA, Rhodes, SJ, Keele, JW, Leymaster, KA, Jirtle, RL, and Smith, TPL. "Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals." Genome Research 12, no. 10 (October 2002): 1496-1506.
Murphy, SK, Wylie, AA, and Jirtle, RL. "Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior." Genomics 71, no. 1 (January 2001): 110-117.
Wylie, AA, Murphy, SK, Orton, TC, and Jirtle, RL. "Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation." Genome Research 10, no. 11 (November 2000): 1711-1718.
Murphy, SK, and Jirtle, RL. "Imprinted genes as potential genetic and epigenetic toxicologic targets." Environmental Health Perspectives 108 Suppl 1 (March 2000): 5-11. (Review)

Recent Grants

Courses

PATHOL 293: Research Independent Study (PATHOL 293: Research Independent Study)

Contact Information

Box 91012
Durham, NC 27708-1012
119 B Wing LSRC, 308 Research Drive
Durham, NC 27708

Education

Ph.D., Wake Forest University (1998)
B.A., University of North Carolina at Charlotte (1992)