My research interests are largely centered around epigenetics and the role of epigenetic modifications in health and disease. My research projects include studies of gynecologic malignancies, including working on approaches to target ovarian cancer cells that survive chemotherapy and later give rise to recurrent disease. I have ongoing collaborative projects in which we investigate the nature of the Developmental Origins of Health and Disease (DOHaD) hypothesis. DOHaD reflects the idea that our early environment plays an important part in shaping our risk of developing neurodevelopmental disorders or other chronic health problems. I am currently focused on preconception exposures in males with studies of the impact of cannabis use on the sperm epigenome and heritability of these effects. My lab is also working on the effects of in utero exposures, with our primary work revolving around the Newborn Epigenetics STudy (NEST), a mother-infant dyad cohort recruited from central North Carolina between 2005 and 2011 and whom we have followed since early pregnancy.
School Division
Environmental Sciences & PolicyEducation
- Ph.D., Wake Forest University (1998)
- B.A., University of North Carolina - Charlotte (1992)
Recent Grants
- The role of ferroptosis in the metastatic ovarian cancer awarded by Ovarian Cancer Research Alliance
- The Southeastern Liver Health Cohort Study awarded by North Carolina State University
- The Southeastern Liver Health Cohort Study awarded by North Carolina State University
- Role of Age-Related Changes in the Tumor Microenvironment on Ovarian Cancer Progression awarded by National Institutes of Health
- Duke Women's Reproductive Health Research Scholars awarded by National Institutes of Health
Recent Publications
- Toxicological Sciences 191, no. 2 ( ): 239 - 252
- Epigenetics : Official Journal of the Dna Methylation Society 17, no. 12 ( ): 1573 - 1589
- Nature Metabolism 4, no. 12 ( ): 1732 - 1745
- Nicotine Tob Res 24, no. 12 ( ): 2003 - 2010
- Epigenetics : Official Journal of the Dna Methylation Society 17, no. 11 ( ): 1446 - 1461