Susan Kay Murphy

Susan Kay Murphy

Associate Professor

Ovarian and cervical cancer epigenetics, imprinted genes in ovarian and cervical cancers, identification of methylation biomarkers of disease, ovarian cancer stem cells, chemotherapeutic response in ovarian cancer, tumor dormancy, the influence of the in utero environment on DNA methylation and risk of disease.

SELECTED PUBLICATIONS

Murphy, Susan K., Abayomi Adigun, Zhiqing Huang, Francine Overcash, Frances Wang, Randy L. Jirtle, Joellen M. Schildkraut, Amy P. Murtha, Edwin S. Iversen, and Cathrine Hoyo. “Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke..” Gene 494, no. 1 (February 15, 2012): 36–43. https://doi.org/10.1016/j.gene.2011.11.062.
Murphy, Susan K., Zhiqing Huang, and Cathrine Hoyo. “Differentially methylated regions of imprinted genes in prenatal, perinatal and postnatal human tissues..” Plos One 7, no. 7 (2012). https://doi.org/10.1371/journal.pone.0040924.
Matsumura, Noriomi, Zhiqing Huang, Seiichi Mori, Tsukasa Baba, Shingo Fujii, Ikuo Konishi, Edwin S. Iversen, Andrew Berchuck, and Susan K. Murphy. “Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer..” Genome Res 21, no. 1 (January 2011): 74–82. https://doi.org/10.1101/gr.108803.110.
Kondoh, Eiji, Seiichi Mori, Ken Yamaguchi, Tsukasa Baba, Noriomi Matsumura, J. Cory Barnett, Regina S. Whitaker, et al. “Targeting slow-proliferating ovarian cancer cells..” Int J Cancer 126, no. 10 (May 15, 2010): 2448–56. https://doi.org/10.1002/ijc.24919.
Yamaguchi, K., M. Mandai, T. Oura, N. Matsumura, J. Hamanishi, T. Baba, S. Matsui, S. K. Murphy, and I. Konishi. “Identification of an ovarian clear cell carcinoma gene signature that reflects inherent disease biology and the carcinogenic processes..” Oncogene 29, no. 12 (March 25, 2010): 1741–52. https://doi.org/10.1038/onc.2009.470.
Lee, Paula S., Vanessa S. Teaberry, Amy E. Bland, Zhiqing Huang, Regina S. Whitaker, Tsukasa Baba, Shingo Fujii, Angeles Alvarez Secord, Andrew Berchuck, and Susan K. Murphy. “Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer..” Int J Cancer 126, no. 6 (March 15, 2010): 1378–89. https://doi.org/10.1002/ijc.24797.
Murphy, Susan K. “Targeting ovarian cancer-initiating cells..” Anticancer Agents Med Chem 10, no. 2 (February 2010): 157–63.
Hoyo, Cathrine, Susan K. Murphy, and Randy L. Jirtle. “Imprint regulatory elements as epigenetic biosensors of exposure in epidemiological studies..” J Epidemiol Community Health 63, no. 9 (September 2009): 683–84. https://doi.org/10.1136/jech.2009.090803.
Matsumura, Noriomi, Zhiqing Huang, Tsukasa Baba, Paula S. Lee, Jason C. Barnett, Seiichi Mori, Jeffrey T. Chang, et al. “Yin yang 1 modulates taxane response in epithelial ovarian cancer..” Mol Cancer Res 7, no. 2 (February 2009): 210–20. https://doi.org/10.1158/1541-7786.MCR-08-0255.
Baba, T., P. A. Convery, N. Matsumura, R. S. Whitaker, E. Kondoh, T. Perry, Z. Huang, et al. “Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells..” Oncogene 28, no. 2 (January 15, 2009): 209–18. https://doi.org/10.1038/onc.2008.374.
Price, Thomas M., Susan K. Murphy, and Edward V. Younglai. “Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors..” Toxicol Sci 96, no. 2 (April 2007): 218–26. https://doi.org/10.1093/toxsci/kfl196.
Weidman, Jennifer R., Dana C. Dolinoy, Susan K. Murphy, and Randy L. Jirtle. “Cancer susceptibility: epigenetic manifestation of environmental exposures..” Cancer J 13, no. 1 (January 2007): 9–16. https://doi.org/10.1097/PPO.0b013e31803c71f2.
Murphy, Susan K., Zhiqing Huang, Yaqing Wen, Monique A. Spillman, Regina S. Whitaker, Lauren R. Simel, Teresa D. Nichols, Jeffrey R. Marks, and Andrew Berchuck. “Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer..” Mol Cancer Res 4, no. 4 (April 2006): 283–92. https://doi.org/10.1158/1541-7786.MCR-05-0138.
Murphy, Susan K., Catherine M. Nolan, Zhiqing Huang, Katerina S. Kucera, Brad A. Freking, Timothy P. L. Smith, Kreg A. Leymaster, Jennifer R. Weidman, and Randy L. Jirtle. “Callipyge mutation affects gene expression in cis: a potential role for chromatin structure..” Genome Research 16, no. 3 (March 2006): 340–46. https://doi.org/10.1101/gr.4389306.
Huang, Zhiqing, Yaqing Wen, Ruby Shandilya, Jeffrey R. Marks, Andrew Berchuck, and Susan K. Murphy. “High throughput detection of M6P/IGF2R intronic hypermethylation and LOH in ovarian cancer..” Nucleic Acids Res 34, no. 2 (2006): 555–63. https://doi.org/10.1093/nar/gkj468.
Berchuck, Andrew, Edwin S. Iversen, Johnathan M. Lancaster, Jennifer Pittman, Jingqin Luo, Paula Lee, Susan Murphy, et al. “Patterns of gene expression that characterize long-term survival in advanced stage serous ovarian cancers..” Clin Cancer Res 11, no. 10 (May 15, 2005): 3686–96. https://doi.org/10.1158/1078-0432.CCR-04-2398.
Murphy, Susan K., Brad A. Freking, Timothy P. L. Smith, Kreg Leymaster, Catherine M. Nolan, Andrew A. Wylie, Heather K. Evans, and Randy L. Jirtle. “Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep..” Mamm Genome 16, no. 3 (March 2005): 171–83. https://doi.org/10.1007/s00335-004-2421-1.
Murphy, S. K., A. A. Wylie, K. J. Coveler, P. D. Cotter, P. R. Papenhausen, V. R. Sutton, L. G. Shaffer, and R. L. Jirtle. “Epigenetic detection of human chromosome 14 uniparental disomy..” Hum Mutat 22, no. 1 (July 2003): 92–97. https://doi.org/10.1002/humu.10237.
Murphy, Susan K., and Randy L. Jirtle. “Imprinting evolution and the price of silence..” Bioessays 25, no. 6 (June 2003): 577–88. https://doi.org/10.1002/bies.10277.
Freking, Brad A., Susan K. Murphy, Andrew A. Wylie, Simon J. Rhodes, John W. Keele, Kreg A. Leymaster, Randy L. Jirtle, and Timothy P. L. Smith. “Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals..” Genome Res 12, no. 10 (October 2002): 1496–1506. https://doi.org/10.1101/gr.571002.
Murphy, S. K., A. A. Wylie, and R. L. Jirtle. “Imprinting of PEG3, the human homologue of a mouse gene involved in nurturing behavior..” Genomics 71, no. 1 (January 2001): 110–17. https://doi.org/10.1006/geno.2000.6419.
Wylie, A. A., S. K. Murphy, T. C. Orton, and R. L. Jirtle. “Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation..” Genome Res 10, no. 11 (November 2000): 1711–18. https://doi.org/10.1101/gr.161600.
Murphy, S. K., and R. L. Jirtle. “Imprinted genes as potential genetic and epigenetic toxicologic targets..” Environ Health Perspect 108 Suppl 1 (March 2000): 5–11. https://doi.org/10.1289/ehp.00108s15.

Recent Grants

Courses

PATHOL 293: Research Independent Study (PATHOL 293: Research Independent Study)

Contact Information

Box 91012
Durham, NC 27708-1012
119 B Wing LSRC, 308 Research Drive
Durham, NC 27708

Education

Ph.D., Wake Forest University (1998)
B.A., University of North Carolina at Charlotte (1992)