Heather M. Stapleton
Heather M. Stapleton
Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
Chair, EEH Program
Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.
In The News
Luz, AL, Kassotis, CD, Stapleton, HM, and Meyer, JN. "The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells." Toxicology (November 7, 2017).
Hammel, SC, Hoffman, K, Lorenzo, AM, Chen, A, Phillips, AL, Butt, CM, Sosa, JA, Webster, TF, and Stapleton, HM. "Associations between flame retardant applications in furniture foam, house dust levels, and residents' serum levels." Environment international 107 (October 2017): 181-189.
Siebenaler, R, Cameron, R, Butt, CM, Hoffman, K, Higgins, CP, and Stapleton, HM. "Serum perfluoroalkyl acids (PFAAs) and associations with behavioral attributes." Chemosphere 184 (October 2017): 687-693.
Hoffman, K, Lorenzo, A, Butt, CM, Hammel, SC, Henderson, BB, Roman, SA, Scheri, RP, Stapleton, HM, and Sosa, JA. "Exposure to flame retardant chemicals and occurrence and severity of papillary thyroid cancer: A case-control study." Environment international 107 (October 2017): 235-242.
Thomas, MB, Stapleton, HM, Dills, RL, Violette, HD, Christakis, DA, and Sathyanarayana, S. "Demographic and dietary risk factors in relation to urinary metabolites of organophosphate flame retardants in toddlers." Chemosphere 185 (October 2017): 918-925.
ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 898: Program Area Seminar (ENVIRON 898: Program Area Seminar)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 780: Environmental Exposure Analysis (ENVIRON 780: Environmental Exposure Analysis)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
area(s) of expertiseEnvironmental Chemistry Environmental Health Toxicology Advisor: ENV Doctoral Program Advisor: TOX Doctoral Program
Durham, NC 27708-0328
450 Research Drive, LSRC Room A220
Durham, NC 27519
Ph.D., University of Maryland, College Park (2003)
M.S., University of Maryland, College Park (2000)
B.S., Long Island University Southhampton College (1997)