Heather M. Stapleton
Heather M. Stapleton
Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
Chair, EEH Program
Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.
In The News
Gibson, EA, Stapleton, HM, Calero, L, Holmes, D, Burke, K, Martinez, R, Cortes, B, Nematollahi, A, Evans, D, Anderson, KA, and Herbstman, JB. "Differential exposure to organophosphate flame retardants in mother-child pairs." Chemosphere 219 (March 2019): 567-573.
Tuttle, AH, Salazar, G, Cooper, EM, Stapleton, HM, and Zylka, MJ. "Choice of vehicle affects pyraclostrobin toxicity in mice." Chemosphere 218 (March 2019): 501-506.
Lefevre, E, Redfern, L, Cooper, EM, Stapleton, HM, and Gunsch, CK. "Acetate promotes microbial reductive debromination of tetrabromobisphenol A during the startup phase of anaerobic wastewater sludge bioreactors." The Science of the Total Environment 656 (March 2019): 959-968.
Kassotis, CD, Kollitz, EM, Hoffman, K, Sosa, JA, and Stapleton, HM. "Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells." The Science of the Total Environment 666 (February 18, 2019): 431-444.
Ingle, ME, Mínguez-Alarcón, L, Carignan, CC, Butt, CM, Stapleton, HM, Williams, PL, Ford, JB, Hauser, R, Meeker, JD, and EARTH Study Team, . "The association of urinary phosphorous-containing flame retardant metabolites and self-reported personal care and household product use among couples seeking fertility treatment." Journal of Exposure Science & Environmental Epidemiology (February 6, 2019).
The placenta: a novel target of sex specific neurotoxicity by fire retardants awarded by North Carolina State University
MRI: Acquisition of a GC Hybrid Orbitrap High Resolution Tandem Mass Spectrometer for Environmental Science awarded by National Science Foundation
Interrogation of molecular mechanisms involved in driving adipogenesis in environmental mixtures and novel analytical techniques for identifying putative causative chemicals awarded by National Institutes of Health
ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 898: Program Area Seminar (ENVIRON 898: Program Area Seminar)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 780: Environmental Exposure Analysis (ENVIRON 780: Environmental Exposure Analysis)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
area(s) of expertiseEnvironmental Chemistry Environmental Health Toxicology Advisor: ENV Doctoral Program Advisor: TOX Doctoral Program
Durham, NC 27708-0328
9 Circuit Drive, Box 90328, LSRC Room A207
Durham, NC 27710
Ph.D., University of Maryland, College Park (2003)
M.S., University of Maryland, College Park (2000)
B.S., Long Island University Southhampton College (1997)