Heather M. Stapleton
Heather M. Stapleton
Dan and Bunny Gabel Associate Professor of Environmental Ethics and Sustainable Environmental Management
Chair, EEH Program
Dr. Stapleton's research focuses on understanding the fate and transformation of organic contaminants in aquatic systems and in indoor environments. Her main focus has been on the bioaccumulation and biotransformation of brominated flame retardants, and specifically polybrominated diphenyl ethers,(PBDEs). Her current research projects explore the routes of human exposure to flame retardant chemicals and examine the way these compounds are photodegraded and metabolized using mass spectrometry to identify breakdown products/metabolites. She uses both in vivo techniques iwth fish, and in vitro techniques with cell cultures to examine metabolism of this varied class of chemicals. Also of interest to Dr. Stapleton is the study of the fate of PBDEs in the environment which may lead to bioaccumulation in aquatic systems and examining their bioavailability under different environmental conditions.
In The News
Luz, AL, Kassotis, CD, Stapleton, HM, and Meyer, JN. "The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells." Toxicology 393 (January 2018): 150-159.
Lefèvre, E, Bossa, N, Gardner, CM, Gehrke, GE, Cooper, EM, Stapleton, HM, Hsu-Kim, H, and Gunsch, CK. "Biochar and activated carbon act as promising amendments for promoting the microbial debromination of tetrabromobisphenol A." Water research 128 (January 2018): 102-110.
Leonetti, CP, Butt, CM, and Stapleton, HM. "Disruption of thyroid hormone sulfotransferase activity by brominated flame retardant chemicals in the human choriocarcinoma placenta cell line, BeWo." Chemosphere 197 (December 28, 2017): 81-88.
Carignan, CC, Mínguez-Alarcón, L, Williams, PL, Meeker, JD, Stapleton, HM, Butt, CM, Toth, TL, Ford, JB, Hauser, R, and EARTH Study Team, . "Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization." Environment international 111 (December 11, 2017): 232-238.
Castorina, R, Bradman, A, Stapleton, HM, Butt, C, Avery, D, Harley, KG, Gunier, RB, Holland, N, and Eskenazi, B. "Current-use flame retardants: Maternal exposure and neurodevelopment in children of the CHAMACOS cohort." Chemosphere 189 (December 2017): 574-580.
The placenta: a novel target of sex specific neurotoxicity by fire retardants awarded by North Carolina State University
Developmental Toxicity of Organophosphate-based Flame Retardants awarded by University of California - Riverside
Interrogation of molecular mechanisms involved in driving adipogenesis in environmental mixtures and novel analytical techniques for identifying putative causative chemicals awarded by National Institutes of Health
ENVIRON 593: Independent Studies and Projects (ENVIRON 593: Independent Studies and Projects)
ENVIRON 898: Program Area Seminar (ENVIRON 898: Program Area Seminar)
ENVIRON 394: Research Independent Study (ENVIRON 394: Research Independent Study)
ENVIRON 780: Environmental Exposure Analysis (ENVIRON 780: Environmental Exposure Analysis)
ENVIRON 360: Environmental Chemistry and Toxicology (ENVIRON 360: Environmental Chemistry and Toxicology)
area(s) of expertiseEnvironmental Chemistry Environmental Health Toxicology Advisor: ENV Doctoral Program Advisor: TOX Doctoral Program
Durham, NC 27708-0328
9 Circuit Drive, Box 90328, LSRC Room A207
Durham, NC 27710
Ph.D., University of Maryland, College Park (2003)
M.S., University of Maryland, College Park (2000)
B.S., Long Island University Southhampton College (1997)